Toronto Travel Forum

I would like to know the best route in taking the bus/train from the airport to the Holiday Inn Express on 111 Lombard Street.

The train does not go to Pearson airport. There is a airport hotel shuttle that will cost about half the price of a cab but if there are two or more traveling together the cab becomes the better option.
Shuttle
http://www.torontoairportexpress.com/pdf/AirportExpress-Schedule.pdf

Alternatively the Toronto transit system runs a express bus service between the airport and the Kipling subway station on the Bloor/Danforth line You would take the subway from Kipling station to Bloor/Yonge and change to the Yonge/Universty/Spadina train southbound to Queen Street station. Walk four blocks east on Queen Street, Two Blocks South on Church streetTurn left on Lombard and walk East about a half block to Number 111.
The map on the ttc website is for route 192 Airport Rocket.
http://www3.ttc.ca/Routes/192/Map.jsp
If you click around on the page where the map is located you will find links to the map of the subway system, it is very easy to use however this will be a slower option than a cab or the shuttle