See www.athensinfoguide.com , section getting around, Greek long distance bus timetable. Here you select Trikala as destination. From Trikala there are regular busses to Kalambaka. For trains www.ose.gr, but all names of places are in Greek even in the English translation. Maybe best is to go from Athens to Larissa and from there to Trikala or Kalambaka.
Maybe it's best to stay 1 nightin Kalambaka otherwise you are traveling all day. Maria
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