Hiya! You can get from Esquel to Bariloche easily by bus, I think Via Bariloche might go via Esquel. If not, its worth stopping off in El Bolson which is a gorgeous little hippie town, and check out the feria, the hand crafted market (which is on Tuesdays, Thursdays, Saturdays and Sundays).
Going by car would give you more of an experience as you can stop along the way, I am sure renting in Esquel and returning in Bariloche is no problem.
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